While very high, isolated doses of Vitamin B6 (over 500 mg daily long-term) can be problematic, Bravo! is a balanced complex. The formulation ensures that B6 works synergistically with other B vitamins (like B1, B12, and folate), as deficiencies in these others often exacerbate B6-related issues. The dosage in Bravo! is formulated to be safe for long-term use, generally adhering to levels of 25-50 mg/day, which is considered safe for most non-deficient adults.