Precision Immune & Pain Support
sub-lingual dosing for inflammation, immune balance & wellness
Low dose naltrexone
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Overview: Product Description
Our Low-Dose Naltrexone (LDN) Spray is designed for targeted, convenient support of immune regulation, chronic pain relief, inflammation control, sleep and mood – all in a smart sub-lingual format. In a world where so many people struggle with unresolved pain, autoimmune stress, persistent fatigue or dysregulated sleep and mood, this unique formulation offers a low-dose pathway to help your body recalibrate. Delivered as a spray under the tongue, LDN at low microgram/milligram levels bypasses much of first-pass liver metabolism, allowing for gentler, more predictable absorption – making it ideal for long-term wellness, chronic conditions and maintenance support.
Why LDN?
"In tiny doses, Naltrexone boosts the production of endorphins in the brain."
Benefits
- Supports immune modulation and helps restore immune balance in chronic conditions.
- Relieves persistent pain, particularly where inflammation or central sensitisation are involved.
- Addresses low-grade neuro-inflammation by inhibiting microglial activation in the central nervous system.
- Promotes improved sleep, better mood stability and overall wellness thanks to modulation of endorphin/endorphin-like pathways.
- Convenient oral-spray format allows for precise dosing, excellent absorption, and bypasses much of liver metabolism (tablet losses) – aligning with modern wellness lifestyles.
More Advantages
- Affordable and accessible compared to many long-term prescription alternatives.
- Well absorbed via sub-lingual spray: estimated >80% absorption compared with high first-pass loss in oral tablets.
- Flexible dosing options: Plain, Peppermint flavour, Very Low dose, Ultra Low dose – meaning we can tailor to your sensitivity, condition and response.
- Low side-effect profile compared with high-dose antagonists and many immunomodulatory drugs, making it suitable for ongoing use and wellness maintenance.
- Shelf-stable, compact spray bottle (9 ml) fits easily into daily routines meaning no large pills, no injections, no complex administration.
Supplement Profile
Active Ingredients
- Naltrexone (Low Dose / Very Low Dose / Ultra Low Dose): The primary active. At low doses, naltrexone acts as a non-selective opioid receptor antagonist (µ, κ, δ) but more importantly in this context: modulates microglial (central nervous system immune) activation, toll-like receptor 4 (TLR4) pathways, and the opioid growth factor–opioid growth factor receptor (OGF-OGFr) axis.
Supplement Facts
- Serving Size: 1 spray under the tongue (approximate; dosage depends on variant)
- Servings per Container: ~60 sprays per 9 ml bottle (varies slightly by variant)
- Format: Oral sub-lingual spray, 9 ml refill bottle
- Packaging: 9 ml plastic spray bottle (shrink-wrapped), shelf-ready
- Active Ingredient per Serving (approximate):
- LDN (Standard strength) – most common variant: refer label
- VLDN (Very Low Dose) – 200 µg (0.2 mg) of naltrexone per spray.
Inactive Ingredients
- Purified water
- Flavour (peppermint)
Allergens
- Present: None reported
- Not Present: Gluten, dairy, soy, nuts, shellfish
Dietary Compliance
- Keto: Yes
- Dairy: No
- Fish: No
- Pork: No
Precautions
- Pregnancy & breastfeeding: Consult your healthcare professional before use. There is limited published safety data for low‐dose naltrexone in pregnancy or lactation.
- Age restrictions: Not intended for children unless prescribed by a qualified medical practitioner.
- As naltrexone is an opioid‐receptor antagonist, it may precipitate withdrawal in individuals actively using opioids.
- Use caution if you have severe liver dysfunction (naltrexone in higher doses is hepatically metabolised—though low dose may mitigate risk).
- Potential interactions with opioid analgesics (may reduce their effect) – always consult your doctor.
- Side Effects: At low doses the side-effect profile is relatively mild, but may include sleep disturbance (especially if taken late), vivid dreams, fatigue or dizziness.
Storage Instructions
- Store in a cool, dry place below 25 °C.
- Protect from direct sunlight and heat.
- Keep the bottle tightly closed when not in use.
- Keep out of reach of children.
- Some variants (e.g., Very Low Dose) are recommended to be refrigerated for best stability, though room temperature storage is acceptable for short term.
Directions
- For the VLDN version (Very Low Dose) – each spray delivers 200 µg (0.2 mg) of naltrexone, approximately 60 sprays per bottle.
- For standard LDN Spray – dosage may vary; follow label instructions.
- Timing: Many users take the spray at bedtime between 18:00-22:00, to align with endorphin modulation and to avoid potential insomnia if taken later.
- How to take: Spray under the tongue (or inside the cheek), hold for 30-60 seconds without swallowing immediately, then swallow. Do not eat, drink or brush teeth immediately before or after use to maximise absorption.
- Initial adjustment period: For first 3 days some users begin before noon to test tolerance (especially with VLDN). From Day 4 onward, evening dosing is recommended for sleep/mood alignment.
- Note: Do not exceed the recommended number of sprays unless instructed by your practitioner. Monitor your response, adjust timing if sleep disturbance occurs.
Low-Dose Naltrexone operates via several complementary mechanisms:
- Microglial modulation & TLR4 antagonism: At low doses, naltrexone antagonises Toll-Like Receptor 4 (TLR4) on microglial cells in the central nervous system, reducing neuro-inflammation, central sensitisation and chronic pain signalling.
- Transient opioid-receptor blockade → endogenous endorphin rebound: By briefly blocking µ-opioid receptors, the body responds by increasing production of endogenous opioids (endorphins and enkephalins), which support mood, natural pain relief and immune balance.
- OGF-OGFr axis modulation (in some uses): Low-dose naltrexone may inhibit the opioid growth factor–opioid growth factor receptor axis, which influences cell proliferation, immune signalling and may have applications in auto-immune and oncologic support.
- Improved absorption via sub-lingual spray: The Integrow formulation bypasses much first-pass hepatic metabolism (tablet naltrexone can lose >80% in liver). The spray format supports faster entry, more predictable blood levels and fewer metabolites that may cause side-effects.
Together, these mechanisms mean the formulation acts not simply as a passive blocker, but as a modulator of immune/inflammatory/endorphin systems – aligning with chronic-support and wellness orientation rather than acute high‐dose antagonism.
- Individuals experiencing persistent or unexplained chronic pain, fibromyalgia, central sensitisation and inflammatory pain syndromes.
- People with auto-immune conditions, low-grade inflammation, immune balance challenges or those interested in immune-resilience support.
- Anyone who struggles with sleep disturbance, mood swings or headaches and wants a gentle modulator rather than heavy pharmaceutical therapy.
- Wellness-oriented users who prefer non-pill, convenient formats (spray) and want a long-term support strategy rather than a short-term fix.
- Adults (18+) seeking to optimise overall immune function, inflammation balance and holistic wellbeing.
🌿 Tailored dosing formats: Choose from Standard LDN, Very Low Dose (VLDN) or Ultra Low Dose (ULDN) – in Plain or Peppermint flavour – so every individual can find their ideal strength and tolerance.
💧 Superior absorption: Our sub-lingual spray format bypasses the digestive tract for rapid uptake and better bioavailability, avoiding the heavy first-pass loss that comes with tablets.
💰 Affordable & long-lasting: Each 9 ml bottle gives around 60 precision sprays, providing up to two months of use – excellent value with no waste.
🌙 Gentle & well-tolerated: Because of its low micro-dosing and efficient absorption, side-effects are minimal, making LDN suitable for long-term wellness and maintenance.
🧬 Science-driven innovation: Grounded in clinical evidence from Medscape and PubMed, LDN works through proven pathways like TLR4 modulation and endorphin balance to support immune regulation and inflammation control.
🌱 Holistic wellness philosophy: As part of the Integrow Health approach, this product supports your whole-body vitality — combining precision science with natural synergy.
🔍 Transparency you can trust: Clear labelling, dosing guidance, and medical disclaimers ensure safe, informed and responsible use.
Science
A 2018 review concluded that LDN “can act as an immunomodulator in multiple autoimmune diseases and malignant tumours as well as alleviate the symptoms of some mental disorders.” PubMed
A 2018 Medscape article reported that at much lower doses (1.5-12 mg) naltrexone appears to function as an anti-inflammatory agent in the central nervous system, via microglial modulation. Medscape
A 2025 meta-analysis of seven randomised trials found LDN may reduce pain in chronic pain syndromes by blocking TLR4 and preventing central sensitisation. PubMed
A 2024 review in Cancer highlighted LDN’s inhibitory effect on cancer cell proliferation via the OGF-OGFr axis, suggesting value as an adjuvant to conventional therapy. MDPI
A 2023 study examined long-term effects of LDN on adipose-derived mesenchymal stem cells and demonstrated changes in immunomodulatory gene expression, supporting its systemic immune impact. PubMed
Note: While promising, LDN remains off-label for many uses and large-scale robust clinical trials are still limited; always consult your medical provider.
Reviews
Chronic pain relief
This is working for my chronic pain. I am going to be consistent in taking this for 6 months to fully realise its pain reduction potential. Thank you Integrow.
Energy increase
Amazing product, I can feel the difference in my energy levels.
Auto-immune help
I use LDN for my auto-immune (Hashimotos). It helps to keep the immune response in check, reduces overall body aches and definitely helps with brain fog/anxiety. The customer service at Integrow is world class.
Inflammation relief
Love the spray application. Would highly recommend. Instantly works for inflammation in my experience.
Depression support
I am steadily weaning myself of my antidepressant and switching over to LDN. What a great product
